2. Sally Owens (Practical Magic)

Played by Sandra Bullock, Sally Owens is both best friend and savior to her onscreen sister played by Nicole Kidman. Not only does Sally have to contend with a family curse that means every man she loves will die, but she also helps her troublemaking sister get out of a really tough spot when her tumultuous relationship goes south! Intensely loyal and a great witch to boot, Sally would be a great sister to have.